ABSTRACT
Background: Some studies have reported that preeclampsia with coronavirus disease 2019 (COVID-19) significantly increases the risk of adverse perinatal outcome until near to three-fold over the normal pregnancy. Preeclampsia pathophysiology in theory, increases the perinatal mortality and morbidity starting from placental injury which is also believed to share the common pathway with COVID-19 infection. Major typical placental injuries for these matters could be apoptotic, necrotic, or pyroptotic. Objective: This study aimed to compare placental damage between those three conditions above in those three typical injuries. Study Design: This was an observational analytic study with cross-sectional setting. Seventy-two pregnant women admitted to hospital consecutively with diagnosis of preeclampsia with COVID-19, Preeclampsia only and COVID-19 only. Diagnosis for preeclampsia was following FIGO criteria with at least one of the severe features. COVID-19 eligible for this study was PCR test confirmative with moderate to severe clinical degree. Placenta were taken after the delivery, and parameters were quantified with immunohistochemistry test for caspase-3, caspase-1, and TNF-alpha representing apoptotic, pyroptotic, and necrotic pathway respectively. Results: Pregnancy with double complications, preeclampsia, and COVID-19, significantly has the highest placental damage on apoptotic, pyroptotic, and necrotic pathway shown from the caspase-3, caspase-1, and TNF-alpha expression in placenta (p <0.05). Moderate to severe degree of COVID-19 resulting higher placental damage compared to preeclampsia in all the three forms (p <0.05). Apoptotic process was the most prominent among other pathways. Conclusion: Preeclampsia with COVID-19 infection showed significant placental damage, with major changes related were apoptosis, inflammation, and necrosis. This data support poor perinatal outcome of pregnancy having preeclampsia and COVID-19 at the same time.
ABSTRACT
The COVID-19 virus has spread throughout the world and has been declared as a global pandemic by WHO. Some population groups are more susceptible to COVID-19 and one of them is pregnant women. Pregnancy increases risks of the COVID-19 especially thrombotic complications. The SARS-CoV-2 infection may vary widely from asymptomatic to severe infection. Some studies have shown that ABO blood group can be a marker of susceptibility to some disease progression. This study aims to investigate relationships between the ABO blood group the COVID-19 infection and its complications in pregnant women at Dr. Moewardi Hospital Surakarta. This study was an observational analytic study with a cross-sectional study design involving 40 pregnant women infected with COVID-19 at Dr. Moewardi Hospital Surakarta. COVID-19 PCR swabs on the women were administered on their oropharynx and nasopharynx and laboratory examination of the ABO blood group in all samples was performed. Comparative data distribution of blood groups in the population and the global population distribution were calculated by Chi Square Goodness of Fit. Comparative data between ABO blood group distributions blood parameters and complications (respiratory thrombotic other infections and death) were calculated by Chi square test and then by One-Way ANOVA. Next correlation tests for the complications of the blood group and the ages applied a multinomial regression. There were significant differences of thrombotic complications on the blood group of pregnant women infected with COVID-19 (p=0.027). Blood type B significantly tended to experience thrombotic complications when compared to other blood groups (p=0.022). The ABO blood group could affect the complication levels in the pregnant women infected with the COVID-19.
ABSTRACT
Penelitian tentang pencegahan kejadian antara suspek probable konfirmasi dan kontak erat COVID-19 antar tenaga kesehatan sangat diperlukan dalam upaya untuk mencegah terjadinya kenaikan angka penularan yang sangat cepat. Dokter dan tenaga medis memiliki risiko yang sangat tinggi terinfeksi COVID-19 sehingga diperlukan pemahaman dan pengetahuan yang matang dari dokter dan tenaga medis dalam melakukan pencegahan dan pengendalian paparan COVID-19.Tujuan: Penelitian ini bertujuan untuk meningkatkan pencegahan kejadian COVID-19 pada anggota POGI muda melalui pemberian materi dan diskusi tentang pencegahan dan pengendalian COVID-19.Metode: Pengabdian ini dilakukan dengan cara diskusi menggunakan metode daring dengan aplikasi zoom memberikan pengertian atau penyuluhan kepada anggota POGI muda cabang Surakarta tentang suspek probable konfirmasi dan kontak erat COVID-19 pencegahan penularan dari COVID-19 screening COVID-19 COVID-19 pada ibu hamil dan masalah lain. Narasumber adalah semua pengabdi yang di bidang obstetri ginekologi dalam rangka penanganan COVID-19 dalam kehamilan. Pelaksanaan diskusi dilakukan di rumah masing-masing anggota POGI muda. Waktu diskusi dilakukan dari bulan April hingga Maret 2021.Hasil: Hasil analisis dengan uji t-test berpasangan didapatkan rata-rata nilai pretest yaitu 77.00 sedangkan rata-rata nilai posttest 92.40 dengan nilai signifikansi p=0.001 (p<0.05). Hasil analisis dengan uji Chi-square didapatkan nilai p<0.001 (p<0.05) dan nilai OR=27.56. Kesimpulan: Terdapat peningkatan pemahaman anggota POGI muda mengenai COVID-19 setelah dilakukan pemberian materi dan diskusi oleh pengabdi dengan nilai signifikansi p=0.001 (p<0.05). Pemberian materi dan diskusi mengenai COVID-19 oleh peneliti mampu memberikan pemahaman 27.56 kali lebih baik dibandingkan sebelum diberikan materi dan diskusi.Kata Kunci: COVID-19 Suspek Probable Konfirmasi Kontak Erat Anggota POGI Muda. Research on the prevention of incidents between suspected probable confirmation and close contact COVID-19 among health workers is needed in an effort to prevent a very rapid increase in transmission rates. Doctors and medical personnel have a very high risk of being infected with COVID-19 so a thorough understanding and knowledge of doctors and medical personnel are needed in preventing and controlling exposure to COVID-19.Objective: This study aims to improve the prevention of the incidence of COVID-19 in young POGI members through providing materials and discussions about the prevention and control of COVID-19.Methods: This service was carried out by means of discussions using an online method with a zoom application providing understanding or counseling to obstetric gynecological residents about suspected probable confirmation and close contact COVID-19 prevention of transmission from COVID-19 screening for COVID-19 in pregnant women. and other problems. The resource persons are all service providers in the field of obstetrics and gynecology in the context of handling COVID-19 in pregnancy. The discussion was held in the homes of each of the young POGI members. The time for discussion is from April 2020 to March 2021.Results: The results of the analysis using paired t-test showed an average pretest value of 77.00 while the average posttest score was 92.40 with a significance value of p = 0.001 (p <0.05). The results of the analysis with the Chi-square test obtained p value <0.001 (p <0.05) and the OR value = 27.56. Conclusion: There was an increase in the understanding of young POGI members about COVID-19 after providing material and discussion by researchers with a significance value of p = 0.001 (p <0.05). The giving of material and discussions about COVID-19 by researchers was able to provide 27.56 times better understanding than before being given material and discussion. Keywords: COVID-19 Suspect Probable Confirmation Close Contact Young POGI Members.